Compounds > 2,6-dichloro-1,7-dimethylpyrazolo[1,2-a]pyrazole-3,5-dione

Page last updated: 2024-08-01 04:12:26

2,6-dichloro-1,7-dimethylpyrazolo[1,2-a]pyrazole-3,5-dione

Description

2,6-dichloro-1,7-dimethylpyrazolo[1,2-a]pyrazole-3,5-dione : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	4221181
CHEMBL ID	1366868
CHEBI ID	116166

Synonyms (16)

Synonym
HMS2595E19
2,6-dichloro-3,5-dimethyl-1h,7h-pyrazolo[1,2-a]pyrazole-1,7-dione
smr000337362
MLS000755688
CHEBI:116166
AKOS005108239
2,6-dichloro-1,7-dimethylpyrazolo[1,2-a]pyrazole-3,5-dione
68654-19-3
HMS3380F15
MS-1404 ,
2,6-dichloro-3,5-dimethyl-1h,7h-[1,2]diazolo[1,2-a]pyrazole-1,7-dione
CHEMBL1366868
DTXSID40400984
Q27198898
SR-01000308357-1
sr-01000308357

Drug Classes (1)

Class	Description
pyrazolopyrazole	Any organic heterobicyclic compound class containing two ortho-fused pyrazole rings.

Protein Targets (16)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	2.2387	AID485294
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	25.1189	AID2147
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	35.4813	AID485281
acid sphingomyelinase	Homo sapiens (human)	Potency	25.1189	AID504937
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	72.6796	AID588453; AID588456
Microtubule-associated protein tau	Homo sapiens (human)	Potency	39.8107	AID1460
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	44.6684	AID485364
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	35.4813	AID1030
chromobox protein homolog 1	Homo sapiens (human)	Potency	100.0000	AID540317
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	50.1187	AID743266
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	39.8107	AID540253
snurportin-1	Homo sapiens (human)	Potency	39.8107	AID540253
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	70.7946	AID2662
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	50.1187	AID504891
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	39.8107	AID540253
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	28.1838	AID624287

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
monobromobimane	0	organobromine compound; pyrazolopyrazole	fluorochrome	0	0		low	0	0	0	0	0	0
monochlorobimane	0	organochlorine compound; pyrazolopyrazole	fluorochrome	0	0		low	0	0	0	0	0	0
dibromobimane	0	organobromine compound; pyrazolopyrazole	fluorochrome	0	0		low	0	0	0	0	0	0

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
Inflammation	0	1	2010	2010	14.0	high	0	0	0	1	0	0
Innate Inflammatory Response	0	1	2010	2010	14.0	high	0	0	0	1	0	0